Abstract: . . .  1 Clinical trials 2.2 Instrumentation 3. Perspectives 3.1 Fluorescence lifetime cancer detection 3.2 Other applications References Abbreviations Ackno wledgements Page 10 Contents A 1. Epidemiology of cancer in western countries A2 Costs of cancer management A3. Lung cancer screening techniques A4. Anatomy and histology of the organs of interest 1. Epithelial tissue 2. Organs of interest A5. Tumour development and staging A6. Instrumentation 1. List of components 2. FLlM software menus 3. Optical design of fluorescence and back-scattering . . .
. . .  tissue compared to tumour 3. Conclusions 4. Further clinical studies 1. Objectives achieved 1. 1 Scientific aspects 1.2 Technical aspects 1.3 Clinical aspects 2. Further developments 2. 1 Clinical trials 2.2 Instrumentation 3. Perspectives 3.1 Fluorescence lifetime cancer detection 3.2 Other applications References Abbreviations Ackno wledgements Page 10 Contents A 1. Epidemiology of cancer in western countries A2 Costs of cancer management A3. Lung cancer screening techniques A4. Anatomy and histology of the organs of interest 1. Epithelial . . .
. . .  transmission e fficiency 5.4 Detection 5.5 Global yield 5.6 Conclusion 1s Fourier analysis a sensible choice? 6.1 Comparison with least square fitting 6.2 Conclusion Influence of tissue optical properties 7.1 Monte-Carlo simulation 7.2 Computer program 7.3 Results Conclusion on endoscopic feasibility 1. Requirements 1.1 Clinical considerations 1.2 Technical considerations 1.3 Instrument oven/iew 2. Excitation light source 2.1 Sine-wave excitation 2.2 Pulsed excitation 2.3 Other possible light sources 3. Optics set-up 3.1 lmage path 3.2 lmage intensifier . . .
. . .  Modulation depth 5.3 Sensitivity to the origin phase 5.4 Correction 6. Conclusions 6.1 Recommendations for clinical examination 6.2 Performance 1. Material and Methods 1.1 Instrumentation 1.2 Tissue sample preparation Page 9 ... V l l l Cancer Detection by Endoscopie Frequency-Domain Fluorescence Lifetime lmaging 2. Case reports 2.1 Case #1: urinary bladder, excitation 514 nm 2.2 Case #2: urinary bladder, med-U V excitation 2.3 Case #3: urinary bladder, excitation 4 1 7 nm 2.4 Case #4: oral cavity, excitation 4 17 nm 2.5 Case #5: oral . . .
. . .  cancer management A3. Lung cancer screening techniques A4. Anatomy and histology of the organs of interest 1. Epithelial tissue 2. Organs of interest A5. Tumour development and staging A6. Instrumentation 1. List of components 2. FLlM software menus 3. Optical design of fluorescence and back-scattering channels 4. Optical design of the RGB channel 5. lnstrumentation cable map 6. Photodiode A 7. Curriculum vitae A8 List of publication  . . .
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