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Abstract: . . . found to be accompanied by a point mutation in exon 3 of the b- catenin gene [1]. However, the histological features, in particular the tubulopapillary pattern, the cytology and immunohistochemical data (such as positivity for cyto- keratins and negativity for neuron-specific enolase and vimentin) were not in accordance with such a diagnosis [17]. The tubulopapillary and microcystic pattern of the carcinoma partially resembled the cystic variant of acinar cell carcinoma . This rare tumor affects men more frequently than women [14], usually reaches great di- mensions and can be encapsulated [15, 25]. It contains macrocysts and microcysts with a cuboidal or cylindrical epithelial cell lining. The tumor cells express pancreatic enzymes, such as . . . . . . b-catenin, which was found to be accompanied by a point mutation in exon 3 of the b- catenin gene [1]. However, the histological features, in particular the tubulopapillary pattern, the cytology and immunohistochemical data (such as positivity for cyto- keratins and negativity for neuron-specific enolase and vimentin) were not in accordance with such a diagnosis [17]. The tubulopapillary and microcystic pattern of the carcinoma partially resembled the cystic variant of acinar cell carcinoma . This rare tumor affects men more frequently than women [14], usually reaches great di- mensions and can be encapsulated [15, 25]. It contains macrocysts and microcysts with a cuboidal or cylindrical epithelial cell lining. The tumor cells express pancreatic . . . . . . Taouli B, Vilgrain V, O’Toole D, Vullierme MP, Terris B, Menu Y (2002) Intraductal papillary mucinous tumors of the pancreas : features with multimodality imaging. J Comput Assist Tomogr 26:223–231 27. Wilentz RE, Su GH, Dai JL, Sparks AB, Argani P, Sohn TA, Yeo CJ, Kern SE, Hruban RH (2000) Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adeno- carcinomas: a new marker of DPC4 inactivation. Am J Pathol 156:37–43 28. Z’Graggen K, Fernandez-del Castillo C, Rattner DW, Sigala H, Warshaw AL (1998) Metastases to the pancreas and their surgical extirpation. Arch Surg 133:413–417 453 . . . . . . Tomogr 26:223–231 27. Wilentz RE, Su GH, Dai JL, Sparks AB, Argani P, Sohn TA, Yeo CJ, Kern SE, Hruban RH (2000) Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adeno- carcinomas: a new marker of DPC4 inactivation. Am J Pathol 156:37–43 28. Z’Graggen K, Fernandez-del Castillo C, Rattner DW, Sigala H, Warshaw AL (1998) Metastases to the pancreas and their surgical extirpation. Arch Surg 133:413–417 453 . . . --3000,4,375,2841,29118
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